Analyzing the Potential Antioxidative Effects of Omega-369 in Preventing Acetaminophen-Induced Liver Damage

Background: As acetaminophen (APAP) toxicity has become more common in many countries, related cases of poisoning, whether deliberate or unintentional, have been identified as a key contributor to acute liver failure. Aime: To discover if omega-369 fatty acids could protect the male mice from effects acetamiophen. Methods: Thirty-five albino were allocated one five groups at random. Group 1 served "negative control" and received single intraperitoneal injection (10 ml/kg) normal saline on eleventh day test following ten days receiving liquid paraffin orally dose 10 ml/kg. The was given group 2 "positive control". 3 Omega 369 (50 mg/kg/80 ml). 4 (100 mg/kg/35 5 N-acetylcysteine mg/kg/10 Omega-369, N-acetylcysteine, via oral gavage for days. Results: had significantly lower levels glutathione peroxidase (GP-X) superoxide dismutase (SOD) than 1, but greater malondialdehyde (MDA). GP-X SOD higher doses omega-369, prior administration, whereas MDA 3, 4, when compared with 2. Conclusion: Omega-369 acids, taken orally, exhibit antioxidative may reduce risk acetaminophen-induced injury.